Clemson's offence powered a 51-45 victory over No. 16 Wake Forest, which might be a watershed moment in the Tigers' quest to reclaim first place in the ACC and the College Football Playoff.

Junior quarterback DJ Uiagalelei, the face of Clemson's offensive struggles, threw for 371 yards and five touchdowns to stay pace with Wake Forest's Sam Hartman.

Uiagalelei's performance was his finest since his freshman year, when he started two games in place of an injured Trevor Lawrence.

Will Shipley, a sophomore running back, rushed for 104 yards and his seventh touchdown.

As a result of failing to keep Hartman and the Demon Deacons under wraps, Clemson may now face more problems on defence than offence.

After allowing at least 250 passing yards for the third game in a row, the Tigers' weakest link is an inexperienced and thin secondary.

Wake is the third team to throw for four touchdowns without an interception against Dabo Swinney's Clemson, and the second with six, joining Ohio State in the Sugar Bowl in 2021.