The Buffalo Bills' secondary took a major hit this weekend as starting safety Micah Hyde was placed on injured reserve with a neck injury.

Hyde, a stalwart member of the Bills' defence for the past six seasons, was taken to the hospital after suffering a neck injury in Week 2's 41-7 victory over the Tennessee Titans.

Hyde did not practise for the Bills this week, and he was already ruled out for Week 3 against the Miami Dolphins. His season is now ended.

The Bills still have one of the league's most outstanding pass defences, but losing Hyde is a significant loss for the NFL's top defence.

In 17 starts for Buffalo, Hyde was a second-team All-Pro with 74 combined tackles, five interceptions, and one sack.